This study concerns the evaluation of natural polymers gum Tiruman and Tamarind seed kernel powder as sustained release matrix forming materials in tablet formulation. The matrix tablets of Diclofenac sodium were prepared by wet granulation technique. Different concentrations (5%, 10%, 15%, 20% w/w with respect to total tablet weight) of both the gums were examined to know their effect on in vitro drug release profile. Tablet weight (200mg) and diameter (8mm) was kept constant. The tablets were evaluated for their hardness, friability, drug content and in vitro drug release. Matrix tablets with 15% w/w tamarind seed kernel powder showed sustained drug delivery beyond 8h. Drug release from the polymers followed first order and the release of the drug from the matrix tablets is by diffusion mechanism. It is concluded that both the gums possess substantial matrix forming property that could be used for sustained drug delivery.
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